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Cells Lacking NF-κB or in Which NF-κB Is Not Activated Vary with Respect to Ability To Sustain Herpes Simplex Virus 1 Replication and Are Not Susceptible to Apoptosis Induced by a Replication-Incompetent Mutant Virus
Earlier we reported that NF-κB is activated by protein kinase R (PKR) in herpes simplex virus 1-infected cells. Here we report that in PKR(−/−) cells the yields of wild-type virus are 10-fold higher than in PKR(+/+) cells. In cells lacking NF-κB p50 (nfkb1), p65 (relA), or both p50 and p65, the yiel...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC523294/ https://ncbi.nlm.nih.gov/pubmed/15479802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.21.11615-11621.2004 |
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