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Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA

The virion host shutoff (vhs) protein encoded by the U(L)41 gene of herpes simplex virus 1 is an endoribonuclease. The enzyme is introduced into the cell during unpackaging of the virion upon entry and selectively degrades mRNA for several hours. The RNase activity ceases after the onset of synthesi...

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Autori principali: Taddeo, Brunella, Sciortino, Maria Teresa, Zhang, Weiran, Roizman, Bernard
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924560/
https://ncbi.nlm.nih.gov/pubmed/17620619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705245104
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