The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function

Autosomal dominant polycystic kidney disease is caused by mutations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), which form an ion channel complex that may mediate ciliary sensory processes and regulate endoplasmic reticulum (ER) Ca(2+) release. Loss of PC1 expression profoundly...

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Foilsithe in:Mol Biol Cell
Main Authors: Padovano, Valeria, Kuo, Ivana Y., Stavola, Lindsey K., Aerni, Hans R., Flaherty, Benjamin J., Chapin, Hannah C., Ma, Ming, Somlo, Stefan, Boletta, Alessandra, Ehrlich, Barbara E., Rinehart, Jesse, Caplan, Michael J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Cell Biology 2017
Ábhair:
Brief Reports
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5231895/
https://ncbi.nlm.nih.gov/pubmed/27881662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-08-0597
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