Design and synthesis of a specific endothelin 1 antagonist: effects on pulmonary vasoconstriction.
The 21-amino acid vasoconstrictor peptide endothelin (Et) contains two disulfide bonds. We investigated the importance of the outer disulfide bond in Et-1 by replacing it with an amide linkage. Bioactivity was assessed in an isolated guinea pig lung preparation (perfused at constant flow with Ringer...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1991
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52312/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1871142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.16.7443 |
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