Design and synthesis of a specific endothelin 1 antagonist: effects on pulmonary vasoconstriction.
The 21-amino acid vasoconstrictor peptide endothelin (Et) contains two disulfide bonds. We investigated the importance of the outer disulfide bond in Et-1 by replacing it with an amide linkage. Bioactivity was assessed in an isolated guinea pig lung preparation (perfused at constant flow with Ringer...
Salvato in:
| Pubblicato in: | Proc Natl Acad Sci U S A |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1991
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52312/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1871142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.16.7443 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|