Design and synthesis of a specific endothelin 1 antagonist: effects on pulmonary vasoconstriction.

The 21-amino acid vasoconstrictor peptide endothelin (Et) contains two disulfide bonds. We investigated the importance of the outer disulfide bond in Et-1 by replacing it with an amide linkage. Bioactivity was assessed in an isolated guinea pig lung preparation (perfused at constant flow with Ringer...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Spinella, M J, Malik, A B, Everitt, J, Andersen, T T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52312/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1871142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.16.7443
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