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Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination
The DNA replication machinery stalls at damaged sites on templates, but normally restarts by switching to a specialized DNA polymerase(s) that carries out translesion DNA synthesis (TLS). In human cells, DNA polymerase η (polη) accumulates at stalling sites as nuclear foci, and is involved in ultrav...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522788/ https://ncbi.nlm.nih.gov/pubmed/15359278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600383 |
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