Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

The DNA replication machinery stalls at damaged sites on templates, but normally restarts by switching to a specialized DNA polymerase(s) that carries out translesion DNA synthesis (TLS). In human cells, DNA polymerase η (polη) accumulates at stalling sites as nuclear foci, and is involved in ultrav...

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Hlavní autoři: Watanabe, Kenji, Tateishi, Satoshi, Kawasuji, Michio, Tsurimoto, Toshiki, Inoue, Hirokazu, Yamaizumi, Masaru
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC522788/
https://ncbi.nlm.nih.gov/pubmed/15359278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600383
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