Targeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models

Although over expression of chimeric FGFR1 kinase consistently leads to the development of AML in the rare Stem Cell Leukemia and Lymphoma syndrome, we now show that overexpression of FGFR1 is also seen in up to 20% of non-syndromic, de novo AML. To determine whether targeting FGFR1 in both of these...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Wu, Qing, Bhole, Aaron, Qin, Haiyan, Karp, Judith, Malek, Sami, Cowell, John K, Ren, Mingqiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226543/
https://ncbi.nlm.nih.gov/pubmed/27391347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10438
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