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Targeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models

Although over expression of chimeric FGFR1 kinase consistently leads to the development of AML in the rare Stem Cell Leukemia and Lymphoma syndrome, we now show that overexpression of FGFR1 is also seen in up to 20% of non-syndromic, de novo AML. To determine whether targeting FGFR1 in both of these...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wu, Qing, Bhole, Aaron, Qin, Haiyan, Karp, Judith, Malek, Sami, Cowell, John K, Ren, Mingqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226543/
https://ncbi.nlm.nih.gov/pubmed/27391347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10438
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