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Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromized mouse model
AML is a heterogeneous disease comprising a large number of subtypes defined by specific chromosome abnormalities. One such subtype carries the t(6;9)(p22;q34) chromosome rearrangement which leads to expression of the DEK-NUP214 chimeric gene, and has a particularly poor outcome. To provide a better...
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| Pubblicato in: | Oncogene |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5064821/ https://ncbi.nlm.nih.gov/pubmed/27065320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.118 |
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