Identification of IFN-γ-producing T cells as the main mediators of the side effects associated to mouse interleukin-15 sustained exposure

Interleukin-15 (IL-15) is a cell growth-factor that regulates lymphocyte function and homeostasis. Its strong immunostimulatory activity coupled with an apparent lack of toxicity makes IL-15 an exciting candidate for cancer therapy, somehow limited by its short half-life in circulation. To increase...

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Foilsithe in:Oncotarget
Main Authors: Scala, Marianna Di, Gil-Fariña, Irene, Olagüe, Cristina, Vales, Africa, Sobrevals, Luciano, Fortes, Puri, Corbacho, David, González-Aseguinolaza, Gloria
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper: Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226487/
https://ncbi.nlm.nih.gov/pubmed/27356750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10264
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