IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression

Recombinant adenoassociated viral vectors (rAAV) have proven to be excellent candidates for gene therapy clinical applications. Recent results showed that cellular immunity to AAV represents a major challenge facing the clinical use of systemic administration of these vectors. Interestingly, no prec...

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Detalhes bibliográficos
Main Authors: Gil-Fariña, Irene, Di Scala, Marianna, Vanrell, Lucia, Olagüe, Cristina, Vales, Africa, High, Katherine A., Prieto, Jesus, Mingozzi, Federico, Gonzalez-Aseguinolaza, Gloria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699534/
https://ncbi.nlm.nih.gov/pubmed/23844082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067748
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