Cell transcriptional state alters genomic patterns of DNA double-strand break repair in human astrocytes

The misrepair of DNA double-strand breaks in close spatial proximity within the nucleus can result in chromosomal rearrangements that are important in the pathogenesis of haematopoietic and solid malignancies. It is unknown why certain epigenetic states, such as those found in stem or progenitor cel...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Yong, Raymund L., Yang, Chunzhang, Lu, Jie, Wang, Huaien, Schlaff, Cody D., Tandle, Anita, Graves, Christian A., Elkahloun, Abdel G., Chen, Xiaoyuan, Zhuang, Zhengping, Lonser, Russell R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226433/
https://ncbi.nlm.nih.gov/pubmed/25517576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6799
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