Cell transcriptional state alters genomic patterns of DNA double-strand break repair in human astrocytes

The misrepair of DNA double-strand breaks in close spatial proximity within the nucleus can result in chromosomal rearrangements that are important in the pathogenesis of haematopoietic and solid malignancies. It is unknown why certain epigenetic states, such as those found in stem or progenitor cel...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Yong, Raymund L., Yang, Chunzhang, Lu, Jie, Wang, Huaien, Schlaff, Cody D., Tandle, Anita, Graves, Christian A., Elkahloun, Abdel G., Chen, Xiaoyuan, Zhuang, Zhengping, Lonser, Russell R.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226433/
https://ncbi.nlm.nih.gov/pubmed/25517576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6799
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