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Cell transcriptional state alters genomic patterns of DNA double-strand break repair in human astrocytes

The misrepair of DNA double-strand breaks in close spatial proximity within the nucleus can result in chromosomal rearrangements that are important in the pathogenesis of haematopoietic and solid malignancies. It is unknown why certain epigenetic states, such as those found in stem or progenitor cel...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yong, Raymund L., Yang, Chunzhang, Lu, Jie, Wang, Huaien, Schlaff, Cody D., Tandle, Anita, Graves, Christian A., Elkahloun, Abdel G., Chen, Xiaoyuan, Zhuang, Zhengping, Lonser, Russell R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226433/
https://ncbi.nlm.nih.gov/pubmed/25517576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6799
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