Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) is a leading cause of liver disease worldwide. However, the molecular basis of how benign steatosis progresses to NASH is incompletely understood, which has limited the identification of therapeutic targets. Here we show that the transcription regulator TAZ (WWTR1...

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Publicat a:Cell Metab
Autors principals: Wang, Xiaobo, Zheng, Ze, Caviglia, Jorge Matias, Corey, Kathleen E., Herfel, Tina M., Masia, Ricard, Chung, Raymond, Lefkowitch, Jay H., Schwabe, Robert F., Tabas, Ira
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226184/
https://ncbi.nlm.nih.gov/pubmed/28068223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.09.016
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