Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) is a leading cause of liver disease worldwide. However, the molecular basis of how benign steatosis progresses to NASH is incompletely understood, which has limited the identification of therapeutic targets. Here we show that the transcription regulator TAZ (WWTR1...

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Veröffentlicht in:Cell Metab
Hauptverfasser: Wang, Xiaobo, Zheng, Ze, Caviglia, Jorge Matias, Corey, Kathleen E., Herfel, Tina M., Masia, Ricard, Chung, Raymond, Lefkowitch, Jay H., Schwabe, Robert F., Tabas, Ira
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226184/
https://ncbi.nlm.nih.gov/pubmed/28068223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.09.016
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