Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) is a leading cause of liver disease worldwide. However, the molecular basis of how benign steatosis progresses to NASH is incompletely understood, which has limited the identification of therapeutic targets. Here we show that the transcription regulator TAZ (WWTR1...

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Publicado en:Cell Metab
Main Authors: Wang, Xiaobo, Zheng, Ze, Caviglia, Jorge Matias, Corey, Kathleen E., Herfel, Tina M., Masia, Ricard, Chung, Raymond, Lefkowitch, Jay H., Schwabe, Robert F., Tabas, Ira
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226184/
https://ncbi.nlm.nih.gov/pubmed/28068223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.09.016
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