Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) is a leading cause of liver disease worldwide. However, the molecular basis of how benign steatosis progresses to NASH is incompletely understood, which has limited the identification of therapeutic targets. Here we show that the transcription regulator TAZ (WWTR1...

Full description

Saved in:
Bibliographic Details
Published in:Cell Metab
Main Authors: Wang, Xiaobo, Zheng, Ze, Caviglia, Jorge Matias, Corey, Kathleen E., Herfel, Tina M., Masia, Ricard, Chung, Raymond, Lefkowitch, Jay H., Schwabe, Robert F., Tabas, Ira
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226184/
https://ncbi.nlm.nih.gov/pubmed/28068223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.09.016
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items