Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction

The binding and contribution of transcription factors (TF) to cell specific gene expression is often deduced from open-chromatin measurements to avoid costly TF ChIP-seq assays. Thus, it is important to develop computational methods for accurate TF binding prediction in open-chromatin regions (OCRs)...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Schmidt, Florian, Gasparoni, Nina, Gasparoni, Gilles, Gianmoena, Kathrin, Cadenas, Cristina, Polansky, Julia K., Ebert, Peter, Nordström, Karl, Barann, Matthias, Sinha, Anupam, Fröhler, Sebastian, Xiong, Jieyi, Dehghani Amirabad, Azim, Behjati Ardakani, Fatemeh, Hutter, Barbara, Zipprich, Gideon, Felder, Bärbel, Eils, Jürgen, Brors, Benedikt, Chen, Wei, Hengstler, Jan G., Hamann, Alf, Lengauer, Thomas, Rosenstiel, Philip, Walter, Jörn, Schulz, Marcel H.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Computational Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224477/
https://ncbi.nlm.nih.gov/pubmed/27899623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1061
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