MT5-MMP Promotes Alzheimer’s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

We previously reported that deficiency of membrane-type five matrix metalloproteinase (MT5-MMP) prevents amyloid pathology in the cortex and hippocampus of 5xFAD mice, and ameliorates the functional outcome. We have now investigated whether the integrity of another important area affected in Alzheim...

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Détails bibliographiques
Publié dans:Front Mol Neurosci
Auteurs principaux: Baranger, Kévin, Bonnet, Amandine E., Girard, Stéphane D., Paumier, Jean-Michel, García-González, Laura, Elmanaa, Wejdane, Bernard, Anne, Charrat, Eliane, Stephan, Delphine, Bauer, Charlotte, Moschke, Katrin, Lichtenthaler, Stefan F., Roman, François S., Checler, Frédéric, Khrestchatisky, Michel, Rivera, Santiago
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2017
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223243/
https://ncbi.nlm.nih.gov/pubmed/28119565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00163
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