Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer’s disease: evidence for a pro-amyloidogenic role of MT1-MMP

Matrix metalloproteinases (MMPs) are pleiotropic endopeptidases involved in a variety of neurodegenerative/neuroinflammatory processes through their interactions with a large number of substrates. Among those, the amyloid precursor protein (APP) and the beta amyloid peptide (Aβ) are largely associat...

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Detalhes bibliográficos
Main Authors: Py, Nathalie A., Bonnet, Amandine E., Bernard, Anne, Marchalant, Yannick, Charrat, Eliane, Checler, Frédéric, Khrestchatisky, Michel, Baranger, Kévin, Rivera, Santiago
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166961/
https://ncbi.nlm.nih.gov/pubmed/25278878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2014.00247
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