Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes

Functional reactivation of p53 pathway, although arduous, can potentially provide a broad-based strategy for cancer therapy owing to frequent p53 inactivation in human cancer. Using a phosphoprotein-screening array, we found that Benzyl Isothiocynate, (BITC) increases p53 phosphorylation in breast c...

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Vydáno v:Sci Rep
Hlavní autoři: Xie, Bei, Nagalingam, Arumugam, Kuppusamy, Panjamurthy, Muniraj, Nethaji, Langford, Peter, Győrffy, Balázs, Saxena, Neeraj K., Sharma, Dipali
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223184/
https://ncbi.nlm.nih.gov/pubmed/28071670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40070
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