Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice

Hepatocellular carcinoma (HCC) has the second lowest 5-year survival rate (~16%) of all tumor types partly owing to the lack of effective therapeutic agents. Withaferin A (WA) is a bioactive molecule derived from Withania somnifera and the present study is designed to systemically investigate the an...

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Vydáno v:Sci Rep
Hlavní autoři: Kuppusamy, Panjamurthy, Nagalingam, Arumugam, Muniraj, Nethaji, Saxena, Neeraj K., Sharma, Dipali
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738353/
https://ncbi.nlm.nih.gov/pubmed/29263422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18190-4
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