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Mechanistic elucidation of the antitumor properties of withaferin A in breast cancer

Withaferin A (WFA) is a steroidal lactone with antitumor effects manifested at multiple levels which are mechanistically obscure. Using a phospho-kinase screening array, we discovered that WFA activated phosphorylation of the S6 kinase RSK in breast cancer cells. Pursuing this observation, we define...

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Detalhes bibliográficos
Main Authors: Nagalingam, Arumugam, Kuppusamy, Panjamurthy, Singh, Shivendra V., Sharma, Dipali, Saxena, Neeraj K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009451/
https://ncbi.nlm.nih.gov/pubmed/24732433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2081
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