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Caspase Inhibition Prevents Tumor Necrosis Factor-α–Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro

How different cell death modes and cell survival pathways cross talk remains elusive. We determined the interrelation of apoptosis, necrosis, and autophagy in tumor necrosis factor (TNF)-α/actinomycin D (ActD) and lipopolysaccharide/D-galactosamine (GalN)-induced hepatotoxicity in vitro and in vivo....

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Bibliografiske detaljer
Udgivet i:Am J Pathol
Main Authors: Ni, Hong-Min, McGill, Mitchell R., Chao, Xiaojuan, Woolbright, Benjamin L., Jaeschke, Hartmut, Ding, Wen-Xing
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222974/
https://ncbi.nlm.nih.gov/pubmed/27616656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.06.009
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