α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

During spreading and migration, the leading edges of cells undergo periodic protrusion–retraction cycles. The functional purpose of these cycles is unclear. Here, using submicrometer polydimethylsiloxane pillars as substrates for cell spreading, we show that periodic edge retractions coincide with p...

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Publicado en:Mol Biol Cell
Autores principales: Meacci, Giovanni, Wolfenson, Haguy, Liu, Shuaimin, Stachowiak, Matthew R., Iskratsch, Thomas, Mathur, Anurag, Ghassemi, Saba, Gauthier, Nils, Tabdanov, Erdem, Lohner, James, Gondarenko, Alexander, Chander, Ashok C., Roca-Cusachs, Pere, O’Shaughnessy, Ben, Hone, James, Sheetz, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2016
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221581/
https://ncbi.nlm.nih.gov/pubmed/27122603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-02-0107
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