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EGFR and HER2 Activate Rigidity Sensing Only on Rigid Matrices

Epidermal growth factor receptor (EGFR) interacts with integrins during cell spreading and motility, but little is known about the role of EGFR in these mechanosensing processes. Here we show, using two different cell lines, that in serum- and EGF-free conditions, EGFR or HER2 activity increase spre...

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Detalhes bibliográficos
Publicado no:Nat Mater
Main Authors: Saxena, Mayur, Liu, Shuaimin, Yang, Bo, Hajal, Cynthia, Changede, Rishita, Hu, Junqiang, Wolfenson, Haguy, Hone, James, Sheetz, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920513/
https://ncbi.nlm.nih.gov/pubmed/28459445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat4893
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