Tropomyosin Controls Sarcomere-like Contractions for Rigidity Sensing and Suppressing Growth on Soft Matrices

Cells test the rigidity of the extracellular matrix by applying forces to it through integrin adhesions. Recent measurements show that these forces are applied via local micrometre-scale contractions, but how contraction force is regulated by rigidity is unknown. Here we performed high temporal- and...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Wolfenson, Haguy, Meacci, Giovanni, Liu, Shuaimin, Stachowiak, Matthew R., Iskratsch, Thomas, Ghassemi, Saba, Roca-Cusachs, Pere, O’Shaughnessy, Ben, Hone, James, Sheetz, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296190/
https://ncbi.nlm.nih.gov/pubmed/26619148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3277
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