α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

During spreading and migration, the leading edges of cells undergo periodic protrusion–retraction cycles. The functional purpose of these cycles is unclear. Here, using submicrometer polydimethylsiloxane pillars as substrates for cell spreading, we show that periodic edge retractions coincide with p...

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Gepubliceerd in:Mol Biol Cell
Hoofdauteurs: Meacci, Giovanni, Wolfenson, Haguy, Liu, Shuaimin, Stachowiak, Matthew R., Iskratsch, Thomas, Mathur, Anurag, Ghassemi, Saba, Gauthier, Nils, Tabdanov, Erdem, Lohner, James, Gondarenko, Alexander, Chander, Ashok C., Roca-Cusachs, Pere, O’Shaughnessy, Ben, Hone, James, Sheetz, Michael P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Cell Biology 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221581/
https://ncbi.nlm.nih.gov/pubmed/27122603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-02-0107
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