Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (The ANAKID Trial)

BACKGROUND: Although Kawasaki disease (KD) is the most common cause of acquired heart disease in children and may result in coronary artery aneurysms (CAA) with an attendant risk of myocardial infarction, there is no recommended therapy to halt progression of arterial wall damage and prevent aneurys...

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Veröffentlicht in:Contemp Clin Trials
Hauptverfasser: Tremoulet, Adriana H, Jain, Sonia, Kim, Susan, Newburger, Jane, Arditi, Moshe, Franco, Alessandra, Best, Brookie, Burns, Jane C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221485/
https://ncbi.nlm.nih.gov/pubmed/27080929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2016.04.002
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