Phase I/IIa Trial of Atorvastatin in Patients With Acute Kawasaki Disease With Coronary Artery Aneurysms

OBJECTIVES: To determine the safety, tolerability, pharmacokinetics, and immunomodulatory effects of a six-week course of atorvastatin in acute KD patients with coronary artery aneurysms (CAA). STUDY DESIGN: We performed a Phase I/IIa, 2-center, dose-escalation study of atorvastatin (0.125-0.75 mg/k...

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Detalhes bibliográficos
Publicado no:J Pediatr
Main Authors: Tremoulet, Adriana H., Jain, Sonia, Jone, Pei-Ni, Best, Brookie M., Duxbury, Elizabeth H., Franco, Alessandra, Printz, Beth, Dominguez, Samuel R., Heizer, Heather, Anderson, Marsha S., Glodé, Mary P., He, Feng, Padilla, Robert L., Shimizu, Chisato, Bainto, Emelia, Pancheri, Joan, Cohen, Harvey J., Whitin, John C., Burns, Jane C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6878161/
https://ncbi.nlm.nih.gov/pubmed/31561960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2019.07.064
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