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Relationship of Leffler (Brønsted) α values and protein folding Φ values to position of transition-state structures on reaction coordinates

The positions of transition states along reaction coordinates (r(‡)) for simple chemical reactions are often estimated from Leffler α values, the slope of plots of ΔG(‡) (activation energy) versus ΔG(0) (equilibrium free energy) for a series of structural variants. Protein folding is more complex th...

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Hlavní autor: Fersht, Alan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC521971/
https://ncbi.nlm.nih.gov/pubmed/15383660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406091101
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