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New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels

To understand why the classical two-state allosteric model of Monod, Wyman, and Changeux explains cooperative oxygen binding by hemoglobin but does not explain changes in oxygen affinity by allosteric inhibitors, we have investigated the kinetic properties of unstable conformations transiently trapp...

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Autores principales: Viappiani, Cristiano, Bettati, Stefano, Bruno, Stefano, Ronda, Luca, Abbruzzetti, Stefania, Mozzarelli, Andrea, Eaton, William A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC521967/
https://ncbi.nlm.nih.gov/pubmed/15385676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405987101
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