Low affinity PEGylated hemoglobin from Trematomus bernacchii, a model for hemoglobin-based blood substitutes

BACKGROUND: Conjugation of human and animal hemoglobins with polyethylene glycol has been widely explored as a means to develop blood substitutes, a novel pharmaceutical class to be used in surgery or emergency medicine. However, PEGylation of human hemoglobin led to products with significantly diff...

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Hlavní autoři: Coppola, Daniela, Bruno, Stefano, Ronda, Luca, Viappiani, Cristiano, Abbruzzetti, Stefania, di Prisco, Guido, Verde, Cinzia, Mozzarelli, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268738/
https://ncbi.nlm.nih.gov/pubmed/22185675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-12-66
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