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Experimental basis for a new allosteric model for multisubunit proteins

Monod, Wyman, and Changeux (MWC) explained allostery in multisubunit proteins with a widely applied theoretical model in which binding of small molecules, so-called allosteric effectors, affects reactivity by altering the equilibrium between more reactive (R) and less reactive (T) quaternary structu...

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Main Authors: Viappiani, Cristiano, Abbruzzetti, Stefania, Ronda, Luca, Bettati, Stefano, Henry, Eric. R., Mozzarelli, Andrea, Eaton, William A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156698/
https://ncbi.nlm.nih.gov/pubmed/25139985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413566111
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