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New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels
To understand why the classical two-state allosteric model of Monod, Wyman, and Changeux explains cooperative oxygen binding by hemoglobin but does not explain changes in oxygen affinity by allosteric inhibitors, we have investigated the kinetic properties of unstable conformations transiently trapp...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC521967/ https://ncbi.nlm.nih.gov/pubmed/15385676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405987101 |
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