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Restoration of an absent G(1) arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

Response to DNA damage and cell-cycle regulation differ markedly between embryonic stem (ES) cells and somatic cells. ES cells require exquisitely sensitive mechanisms to maintain genomic integrity and do so, in part, by suppressing spontaneous mutation. Spontaneous mutation frequency in somatic cel...

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Autors principals: Hong, Yiling, Stambrook, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC521944/
https://ncbi.nlm.nih.gov/pubmed/15452351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401346101
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