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Ionizing radiation is a potent inducer of mitotic recombination in mouse embryonic stem cells

Maintenance of genomic integrity in embryonic cells is pivotal to proper embryogenesis, organogenesis and to the continuity of species. Cultured mouse embryonic stem cells (mESCs), a model for early embryonic cells, differ from cultured somatic cells in their capacity to remodel chromatin, in their...

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Bibliographic Details
Main Authors: Denissova, Natalia G., V.Tereshchenko, Irina, Cui, Eric, Stambrook, Peter J, Shao, Changshun, Tischfield, Jay A.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172342/
https://ncbi.nlm.nih.gov/pubmed/21802432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2011.06.017
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