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Restoration of an absent G(1) arrest and protection from apoptosis in embryonic stem cells after ionizing radiation
Response to DNA damage and cell-cycle regulation differ markedly between embryonic stem (ES) cells and somatic cells. ES cells require exquisitely sensitive mechanisms to maintain genomic integrity and do so, in part, by suppressing spontaneous mutation. Spontaneous mutation frequency in somatic cel...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC521944/ https://ncbi.nlm.nih.gov/pubmed/15452351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401346101 |
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