Efficacy of PLD-118, a Novel Inhibitor of Candida Isoleucyl-tRNA Synthetase, against Experimental Oropharyngeal and Esophageal Candidiasis Caused by Fluconazole-Resistant C. albicans

PLD-118, formerly BAY 10-8888, is a synthetic antifungal derivative of the naturally occurring β-amino acid cispentacin. We studied the activity of PLD-118 in escalating dosages against experimental oropharyngeal and esophageal candidiasis (OPEC) caused by fluconazole (FLC)-resistant Candida albican...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Petraitis, Vidmantas, Petraitiene, Ruta, Kelaher, Amy M., Sarafandi, Alia A., Sein, Tin, Mickiene, Diana, Bacher, John, Groll, Andreas H., Walsh, Thomas J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2004
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521932/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15388459/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.10.3959-3967.2004
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