Efficacy, Plasma Pharmacokinetics, and Safety of Icofungipen, an Inhibitor of Candida Isoleucyl-tRNA Synthetase, in Treatment of Experimental Disseminated Candidiasis in Persistently Neutropenic Rabbits

Icofungipen (formerly PLD-118) is a synthetic derivative of the naturally occurring β-amino acid cispentacin that blocks isoleucyl-tRNA synthetase, resulting in the inhibition of protein synthesis and growth of fungal cells. We investigated the efficacy, plasma pharmacokinetics, and safety of icofun...

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Main Authors: Petraitiene, Ruta, Petraitis, Vidmantas, Kelaher, Amy M., Sarafandi, Alia A., Mickiene, Diana, Groll, Andreas H., Sein, Tin, Bacher, John, Walsh, Thomas J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087633/
https://ncbi.nlm.nih.gov/pubmed/15855534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.2084-2092.2005
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