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Antibodies Targeting Closely Adjacent or Minimally Overlapping Epitopes Can Displace One Another

Here we describe how real-time label-free biosensors can be used to identify antibodies that compete for closely adjacent or minimally overlapping epitopes on their specific antigen via a mechanism of antibody displacement. By kinetically perturbing one another’s binding towards their antigen via th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Abdiche, Yasmina Noubia, Yeung, Andy Yik, Ni, Irene, Stone, Donna, Miles, Adam, Morishige, Winse, Rossi, Andrea, Strop, Pavel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218414/
https://ncbi.nlm.nih.gov/pubmed/28060885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169535
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