High-Throughput Epitope Binning Assays on Label-Free Array-Based Biosensors Can Yield Exquisite Epitope Discrimination That Facilitates the Selection of Monoclonal Antibodies with Functional Activity

Here, we demonstrate how array-based label-free biosensors can be applied to the multiplexed interaction analysis of large panels of analyte/ligand pairs, such as the epitope binning of monoclonal antibodies (mAbs). In this application, the larger the number of mAbs that are analyzed for cross-block...

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Detalhes bibliográficos
Main Authors: Abdiche, Yasmina Noubia, Miles, Adam, Eckman, Josh, Foletti, Davide, Van Blarcom, Thomas J., Yeung, Yik Andy, Pons, Jaume, Rajpal, Arvind
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961344/
https://ncbi.nlm.nih.gov/pubmed/24651868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092451
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