A Nucleotide Binding Motif in Hepatitis C Virus (HCV) NS4B Mediates HCV RNA Replication

Hepatitis C virus (HCV) is a major cause of viral hepatitis. There is no effective therapy for most patients. We have identified a nucleotide binding motif (NBM) in one of the virus's nonstructural proteins, NS4B. This structural motif binds and hydrolyzes GTP and is conserved across HCV isolat...

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Pubblicato in:J Virol
Autori principali: Einav, Shirit, Elazar, Menashe, Danieli, Tsafi, Glenn, Jeffrey S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2004
Soggetti:
Replication
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521822/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15452248/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.20.11288-11295.2004
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