A Rab-GAP TBC Domain Protein Binds Hepatitis C Virus NS5A and Mediates Viral Replication

Hepatitis C virus (HCV) is an important cause of liver disease worldwide. Current therapies are inadequate for most patients. Using a two-hybrid screen, we isolated a novel cellular binding partner interacting with the N terminus of HCV nonstructural protein NS5A. This partner contains a TBC Rab-GAP...

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Detalhes bibliográficos
Main Authors: Sklan, Ella H., Staschke, Kirk, Oakes, Tina M., Elazar, Menashe, Winters, Mark, Aroeti, Benjamin, Danieli, Tsafi, Glenn, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045567/
https://ncbi.nlm.nih.gov/pubmed/17686842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01249-07
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