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The Hepatitis C virus (HCV) NS4B RNA binding inhibitor, clemizole, is highly synergistic with HCV protease inhibitors
BACKGROUND: We recently identified a compound, clemizole hydrochloride, that inhibits NS4B’s RNA binding and HCV replication. Although significant, clemizole’s antiviral effect is moderate (8μM EC50 against an HCV-2a clone). We hypothesized that combination of clemizole with other anti-HCV agents ca...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3008401/ https://ncbi.nlm.nih.gov/pubmed/20486856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/653080 |
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