Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein Response

Epithelial-to-mesenchymal transition (EMT) is linked to tumor invasion, drug resistance and aggressive disease and this is largely dependent on the cell's microenvironment. Acriflavine (ACF) is an old antibacterial drug recently also suggested as anticancer agent and HIF inhibitor. We wanted to...

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Bibliografische gegevens
Gepubliceerd in:Transl Oncol
Hoofdauteurs: Dekervel, Jeroen, Bulle, Ashenafi, Windmolders, Petra, Lambrechts, Diether, Van Cutsem, Eric, Verslype, Chris, van Pelt, Jos
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Neoplasia Press 2016
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Original article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217771/
https://ncbi.nlm.nih.gov/pubmed/27987431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2016.11.008
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