Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein Response

Epithelial-to-mesenchymal transition (EMT) is linked to tumor invasion, drug resistance and aggressive disease and this is largely dependent on the cell's microenvironment. Acriflavine (ACF) is an old antibacterial drug recently also suggested as anticancer agent and HIF inhibitor. We wanted to...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Dekervel, Jeroen, Bulle, Ashenafi, Windmolders, Petra, Lambrechts, Diether, Van Cutsem, Eric, Verslype, Chris, van Pelt, Jos
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2016
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217771/
https://ncbi.nlm.nih.gov/pubmed/27987431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2016.11.008
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