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The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt
The Akt protein, a serine/threonine kinase, plays important roles in cell survival, apoptosis, and oncogenes. Akt is translocated to the plasma membrane for activation. Akt-membrane binding is mediated by direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinositol 3,4,5...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5217684/ https://ncbi.nlm.nih.gov/pubmed/27872186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752816 |
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