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Structural and Biophysical Characterization of the Interactions between Calmodulin and the Pleckstrin Homology Domain of Akt

The translocation of Akt, a serine/threonine kinase, to the plasma membrane is a critical step in the Akt activation pathway. It is established that membrane binding of Akt is mediated by direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinositol 3,4,5-trisphosphate (P...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Agamasu, Constance, Ghanam, Ruba H., Saad, Jamil S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646410/
https://ncbi.nlm.nih.gov/pubmed/26391397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.673939
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